General Cell Lines and Cell Cultures
Eurofins Discoverx Ready-to-Assay P2Y4 Purinergic Receptor Frozen Cells, 2 Vials of Cells. (HTS211RTA)
The Ready-to-Assay P2Y4 Purinergic Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. ATP, UTP) based activation of P2RY4 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses P2RY4, a naturally Gq coupled GPCR. Upon activation of P2RY4, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Biotium CDX2 (GI Epithelial Marker) (CDX2/2951R), CF594 conjugate, 0.1mg/mL
The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher
Eurofins Discoverx ChemiScreen LPA2 Lysophospholipid Receptor Stable Cell Line, 2 vials. (HTS207C)
The ChemiScreen LPA2 Lysophospholipid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. LPA) based activation of LPAR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses LPAR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of LPAR2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
ATCC Escherichia coli; Quantitative DNA
Quantitative Genomic DNA from Escherichia coli strain O111 (ATCC BAA-2440) can be used for assay development, verification, and validation as well as monitoring of day-to-day test variation and lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine bacterial load.
Eurofins Discoverx Ready-to-Assay CX3CR1 Chemokine Receptor Frozen Cells, 2 Vials of Cells. (HTS015RTA)
The Ready-to-Assay CX3CR1 Chemokine Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. fractalkine) based activation of CX3CR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CX3CR1 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CX3CR1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Genscript Corporation CHO-K1/GALR2 Stable Cell Line
Recombinant CHO-K1 cells stably overexpress human galanin receptor 2 (GALR2) on the surface and contain high levels of G protein G q to couple with the receptor in downstream signaling pathways
Eurofins Discoverx PathHunter U2OS IL2RB/IL2RG/IL2RA Dimerization Cell Line, 2 vials. (93-1003C3)
The PathHunter IL2RB/IL2RG/IL2RA Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-2) induced dimerization of IL2RB/IL2RG/IL2RA receptors. This product uses EFC technology. The cell line included overexpresses IL2RB target protein fused to PK alongside IL2RG target protein fused to EA and untagged ILR2A. Upon ligand-induced dimerization of IL2RB/IL2RG/IL2RA, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/interleukins.
Eurofins Discoverx Ready-to-Assay α2A Adrenergic Receptor Frozen Cells, 2 Vials of Cells. (HTS096RTA)
The Ready-to-Assay α2A Adrenergic Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. epinephrine and norepinephrine) based activation of ADRA2A GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses ADRA2A alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of ADRA2A, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Electron Microscopy Sciences Precision Light Guide GI-20-6 with Stay-Put Gooseneck, 20" OAL, 6 mm glass diameter
Designed for use with microscopes, boroscopes, and endoscopes. Flexible and versatile, the light guides are ideal for a host of scientific, quality control and electronic applications. All of our light guides are backed by a full one-year warranty. Applications in stereochemistry, high/low contrast, optical comparators, IC/Semicondoctor etching and printing, automatic test equipment, profile projectors, and quality control.
Features fiber bundles that have been designed to provide brilliant specimen cross lightning from above and below. Only the finest quality optical class used. End fitting are polished stainless steel.
OAL: 20"
Diameter: 6 mm glass
ATCC NCI-H1184; Small Cell Lung Cancer; Human (Homo sapiens)
NCI-H1184 [H1184] are lymphoblasts isolated from the lungs of a 42-year-old, White male with stage L carcinoma. This product can be used for cancer research.
Eurofins Discoverx ChemiScreen CCR7 Chemokine Receptor Stable Cell Line, 2 vials. (HTS012C)
The ChemiScreen CCR7 Chemokine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CCL19) based activation of CCR7 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CCR7 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CCR7, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Charles River Labs Cell Solutions PB CD8 CELLS- POS SEL CRYO 10M
For Research Use Only. Human Normal Peripheral Blood CD8+ Cytotoxic T Cells - Cryopreserved, 10 million cells/vial. Isolated using POSITIVE immunomagnetic cell separation procedures.
Biochain Institute Inc Paraffin Tissue Section - Human Adult Normal: Stomach, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
ATCC Methanococcus voltae; Strain A3; genomic DNA
Genomic DNA isolated from Methanococcus voltae strain A3 (ATCC BAA-1334). This product can be used in PCR and other molecular biology applications.